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GENOME

Whole Genome

“You are genetically unique”. Hence, your genes, or more specifically the variations within those genes, define everything from your physical characteristics (like eye color or hair type) to your predisposition to complex diseases. Genetic predisposition to a disease simply means an increased likelihood of you developing that disease, based on your genetic makeup that you inherited from your parents, caused due to small genetic variations. These are unique genetic signatures of yourself (hence the name of our report - Genome Rich Signature™), that act as indicators of risk of developing disease(s) or extent of predisposition to that disease(s).

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Whole Exome

Genome sequencing determines the complete DNA sequence of an individual’s genome at a single time. “Genome” is sum of all genes and a lot more genetic information, that is present in every individual. On the other hand, an “Exome” is simply defined as “the expressible genome”, which contains all genetic information that exclusively belong to genes only (no other content). We, human beings, are estimated to have around 20000-25000 genes in our genomes, which, as described above, defines every characteristic we possess.

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MICROBIOME

Microbiome

Apart from the genetic influences, your microbiome plays a unique role in disease predisposition. Specifically, the human gut microbiota plays a critical role in maintaining health, influenced by a vital balance between your diet and microbiome. Your food influences the type and diversity of your gut microbiome, which in-turn influences how you digest certain foods. This two way interaction between food and gut microbiota plays a huge role in your diet, nutrition, general wellbeing and health.

Your gut microbiome may vary depending on geography, gender, culture and demographics, genetics (of your own and that of the population), diet, age and many environmental factors, rendering the gut microbiome of every individual to be “unique”. However, this variation follows certain larger patterns, and understanding these patterns provide you with an opportunity to maintain and/or modulate your microbiome towards better health benefits, thus making it critical to know your gut microbiome.

Your gut microbiome is highly diverse, but mostly dominated by thousands of different bacterial species. This diverse community of bacteria is composed of a small number of abundant species plus a large number of rare or low abundance species. The differential abundance and functions of these abundant and rare species effectively influence your gut health. Hence it is imperative to analyze both the rare and the abundant bacterial species, and our microbiome sequencing analysis provides you with an optimized platform to achieve this.

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Microbiome Plus

Even though your gut microbiome is dominated mostly by bacterial species, it is also enriched with various other microorganisms, including fungi, protozoa, metazoa (nematodes), and viruses. Together, these diverse classes of microorganisms, establish a sophisticated interplay between your microbiome, your immune system and metabolism, influencing key aspects of your health and wellbeing.

Just like the bacterial species, these other players in the gut also vary uniquely depending on geography, gender etc., but also follows certain larger patterns. Understanding these patterns provide you with an opportunity to infer on a range of functions, from your digestive to metabolic capabilities, your nutrient requirements to diet, your disease predisposition to health benefits, all associated with your gut microbiome.

Overall, the differential abundance and functions of all these classes effectively influence many larger aspects of your health, making it imperative to identify, characterize and analyze each of these classes. Our metagenomic sequencing analyses accomplishes this expansive procedure by unrestricted sequencing of the genomes of all microorganisms present in your gut, followed by a comprehensive analysis of your gut microbiome.

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